Article
Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2009
Spach Karen M, Blake Melissa, Bunn Janice Y, McElvany Ben, Noubade Rajkumar, Blankenhorn Elizabeth P, Teuscher Cory
Abstract excerpt
Multiple sclerosis is a sexually dimorphic, demyelinating disease of the CNS, and experimental allergic encephalomyelitis (EAE) is its principal autoimmune model. Young male SJL/J mice are relatively resistant to EAE whereas older males and SJL/J females of any age are susceptible. By comparing a...
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