Association of NAT2 gene polymorphisms with susceptibility to esophageal and gastric cancers in the Kashmir Valley.

doi:10.1016/j.arcmed.2009.06.009

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Article

Association of NAT2 gene polymorphisms with susceptibility to esophageal and gastric cancers in the Kashmir Valley.

Archives of medical research - 1 Jul 2009

Malik Manzoor Ahmad, Upadhyay Rohit, Modi Dinesh Raj, Zargar Showket Ali, Mittal Balraj

Abstract excerpt

BACKGROUND AND AIMS: The high incidence of gastrointestinal cancers in the Kashmir Valley has been attributed to the presence of many chemical carcinogens such as nitrosamines and heterocyclic amines in tobacco and salted tea. Due to functional polymorphisms of the N-acetyltransferase 2 (NAT2) gene, there may be interindividual differences in the metabolism of heterocyclic amines. We undertook this study to...

Topics

Aged
Alleles
Arylamine N-Acetyltransferase
Case-Control Studies
Esophageal Neoplasms
Female
Genetic Predisposition to Disease
Haplotypes
Humans
India
Male
Middle Aged
Polymorphism, Genetic
Risk Factors
Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 19766908
DOI: 10.1016/j.arcmed.2009.06.009

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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