Article
Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.
American journal of epidemiology - 1 Oct 2007
Sanderson Simon, Salanti Georgia, Higgins Julian
Abstract excerpt
Bladder cancer is an increasingly important international public health problem, with over 330,000 new cases being diagnosed each year worldwide. In a systematic review and evidence synthesis, the authors investigated the joint effects of the N-acetyltransferase genes NAT1 and NAT2 and cigarette smoking on bladder carcinogenesis. Studies were identified through an exhaustive search of multiple electronic...
Topics
- Amines
- Arylamine N-Acetyltransferase
- Bayes Theorem
- Genetic Variation
- Genotype
- Humans
- Isoenzymes
- Polymorphism, Genetic
- Risk Assessment
- Risk Factors
- Smoking