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Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

17 Apr 2015

Abstract excerpt

To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC(1280) library (Sigma). Twenty-five compounds were defined as hits with activity in all leukemia subgroups (<50% cell survival compared with control) at...

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PMID: 25885427
DOI: 10.1038/bcj.2015.31

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