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Article

Anticancer Properties of Distinct Antimalarial Drug Classes

31 Dec 2013

Abstract excerpt

We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductase) inhibitors effected potent inhibition of proliferation with IC50s in the nM- low µM range, whereas a DHODH (dihydroorotate dehydrogenase) and a putative kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24391728
DOI: 10.1371/journal.pone.0082962

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