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Article

Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.

Neural plasticity - 1 Jan 2015

Paesler Katharina, Xie Kan, Hettich Moritz M, Siwek Magdalena E, Ryan Devon P, Schröder Susanne, Papazoglou Anna, Broich Karl, Müller Ralf, Trog Astrid, Garthe Alexander, Kempermann Gerd, Weiergräber Marco, Ehninger Dan

Abstract excerpt

Alzheimer's disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on synaptic plasticity, learning, and memory. To analyze if increased levels of p-eIF2α indeed promote AD-related neurocognitive impairments, we crossed 5xFAD transgenic mice...

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Identifiers

PMID: 25883808
DOI: 10.1155/2015/825157
PMCID: PMC4391319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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