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Article

Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.

The Journal of biological chemistry - 29 May 2015

Samse Kaitlen, Emathinger Jacqueline, Hariharan Nirmala, Quijada Pearl, Ilves Kelli, Völkers Mirko, Ormachea Lucia, De La Torre Andrea, Orogo Amabel M, Alvarez Roberto, Din Shabana, Mohsin Sadia, Monsanto Megan, Fischer Kimberlee M, Dembitsky Walter P, Gustafsson Åsa B, Sussman Mark A

Abstract excerpt

Human cardiac progenitor cells (hCPC) improve heart function after autologous transfer in heart failure patients. Regenerative potential of hCPCs is severely limited with age, requiring genetic modification to enhance therapeutic potential. A legacy of work from our laboratory with Pim1 kinase reveals effects on proliferation, survival, metabolism, and rejuvenation of hCPCs in vitro and in vivo. We demonstrate...

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Identifiers

PMID: 25882843
DOI: 10.1074/jbc.M114.617431
PMCID: PMC4447967

Genes

CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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