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Article

Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells.

Circulation research - 22 Jun 2012

Quijada Pearl, Toko Haruhiro, Fischer Kimberlee M, Bailey Brandi, Reilly Patrick, Hunt Kristin D, Gude Natalie A, Avitabile Daniele, Sussman Mark A

Abstract excerpt

RATIONALE: Bone marrow-derived cells to treat myocardial injury improve cardiac function and support beneficial cardiac remodeling. However, survival of stem cells is limited due to low proliferation of transferred cells. OBJECTIVE: To demonstrate long-term potential of c-kit(+) bone marrow stem cells (BMCs) enhanced with Pim-1 kinase to promote positive cardiac remodeling. METHODS AND RESULTS: Lentiviral...

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Source

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Identifiers

PMID: 22619278
DOI: 10.1161/CIRCRESAHA.112.265207
PMCID: PMC3398618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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