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Article

Rejuvenation of human cardiac progenitor cells with Pim-1 kinase.

Circulation research - 25 Oct 2013

Mohsin Sadia, Khan Mohsin, Nguyen Jonathan, Alkatib Monique, Siddiqi Sailay, Hariharan Nirmala, Wallach Kathleen, Monsanto Megan, Gude Natalie, Dembitsky Walter, Sussman Mark A

Abstract excerpt

RATIONALE: Myocardial function is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically challenged heart. However, advanced age, comorbidities, and myocardial injury in patients with heart failure constrain the proliferation, survival, and regenerative capacity of hCPCs. Rejuvenation of senescent hCPCs will improve the outcome of regenerative therapy for a substantial...

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Identifiers

PMID: 24044948
DOI: 10.1161/CIRCRESAHA.113.302302
PMCID: PMC3999968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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