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Developing Ultrasensitive Library-Aliquot-Based Droplet Digital PCR for Detecting T790M in Plasma-Circulating Tumor DNA of Non-small-Cell-Lung-Cancer Patients.

Analytical chemistry - 2 Oct 2018

Yang Ke, Li Jun, Zhao Jiuzhou, Ren Pengfei, Wang Zhizhong, Wei Bing, Dong Bing, Sun Rui, Wang Xiaoyan, Groen Harry J M, Ma Jie, Guo Yongjun

Abstract excerpt

A T790M secondary mutation in epidermal-growth-factor receptor (EGFR) is the most well-established EGFR-tyrosine-kinase-inhibitor (TKI) resistance marker in non-small-cell lung cancer (NSCLC). The current methods to rapidly and accurately detect T790M in clinical practice are not satisfactory because of several obstacles, including the unavailability of tumor-tissue rebiopsies and the low DNA copy number of T790M...

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Identifiers

PMID: 30156405
DOI: 10.1021/acs.analchem.8b01776

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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