Article

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

2017-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150,134 European ancestry individuals and s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec9b677d-9cd3-595c-a24f-373b25367d99
DOI: 10.1101/110833

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidneyDOI 10.1101/110833Read

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the KidneySemantic proximity Read

Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressureSemantic proximity Read

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.Semantic proximity Read

Association analyses of predicted loss-of-function variants prioritized 15 genes as blood pressure regulatorsSemantic proximity Read

Loci influencing blood pressure identified using a cardiovascular gene-centric array.Semantic proximity Read

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.Semantic proximity Read

Blood pressure loci identified with a gene-centric array.Semantic proximity Read

Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressureSemantic proximity Read

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertensionSemantic proximity Read

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension.Semantic proximity Read

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Semantic proximity Read

Association Analyses of Predicted Loss-of-Function Variants Prioritized 15 Genes as Blood Pressure Regulators.Semantic proximity Read