Article
A meta-analysis of gene expression signatures of blood pressure and hypertension.
PLoS genetics - 1 Mar 2015
Huan Tianxiao, Esko Tõnu, Peters Marjolein J, Pilling Luke C, Schramm Katharina, Schurmann Claudia, Chen Brian H, Liu Chunyu, Joehanes Roby, Johnson Andrew D, Yao Chen, Ying Sai-Xia, Courchesne Paul, Milani Lili, Raghavachari Nalini, Wang Richard, Liu Poching, Reinmaa Eva, Dehghan Abbas, Hofman Albert, Uitterlinden André G, Hernandez Dena G, Bandinelli Stefania, Singleton Andrew, Melzer David, Metspalu Andres, Carstensen Maren, Grallert Harald, Herder Christian, Meitinger Thomas, Peters Annette, Roden Michael, Waldenberger Melanie, Dörr Marcus, Felix Stephan B, Zeller Tanja, Vasan Ramachandran, O'Donnell Christopher J, Munson Peter J, Yang Xia, Prokisch Holger, Völker Uwe, van Meurs Joyce B J, Ferrucci Luigi, Levy Daniel
Abstract excerpt
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes...
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