Article
Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 gene.
PloS one - 1 Jan 2015
Faber Bart W, Abdul Kadir Khamisah, Rodriguez-Garcia Roberto, Remarque Edmond J, Saul Frederick A, Vulliez-Le Normand Brigitte, Bentley Graham A, Kocken Clemens H M, Singh Balbir
Abstract excerpt
Infection with Plasmodium knowlesi, a zoonotic primate malaria, is a growing human health problem in Southeast Asia. P. knowlesi is being used in malaria vaccine studies, and a number of proteins are being considered as candidate malaria vaccine antigens, including the Apical Membrane Antigen 1 (AMA1). In order to determine genetic diversity of the ama1 gene and to identify epitopes of AMA1 under strongest immune...
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