Genetic diversity and natural selection of Plasmodium knowlesi merozoite surface protein 1 paralog gene in Malaysia.

doi:10.1186/s12936-018-2256-y

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Article

Genetic diversity and natural selection of Plasmodium knowlesi merozoite surface protein 1 paralog gene in Malaysia.

Malaria journal - 14 Mar 2018

Ahmed Md Atique, Fauzi Muh, Han Eun-Taek

Abstract excerpt

BACKGROUND: Human infections due to the monkey malaria parasite Plasmodium knowlesi is on the rise in most Southeast Asian countries specifically Malaysia. The C-terminal 19 kDa domain of PvMSP1P is a potential vaccine candidate, however, no study has been conducted in the orthologous gene of P. knowlesi. This study investigates level of polymorphisms, haplotypes and natural selection of full-length pkmsp1p in...

Topics

Amino Acid Sequence
Base Sequence
Genetic Variation
Haplotypes
Malaysia
Merozoite Surface Protein 1
Phylogeny
Plasmodium knowlesi
Selection, Genetic

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PMID: 29540177
DOI: 10.1186/s12936-018-2256-y
PMCID: PMC5853062

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