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Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population.

Molecular biology and evolution - 1 Apr 2007

Gunasekera Anusha M, Wickramarachchi Thilan, Neafsey Daniel E, Ganguli Ishani, Perera Lakshman, Premaratne Prasad H, Hartl Daniel, Handunnetti Shiroma M, Udagama-Randeniya Preethi V, Wirth Dyann F

Abstract excerpt

Plasmodium vivax apical membrane antigen 1 (PvAMA-1) is an important malaria vaccine candidate. We present the first comprehensive analysis of nucleotide diversity across the entire PvAMA-1 gene using a single population sample from Sri Lanka. In contrast to what has been observed at the AMA-1 locus of Plasmodium falciparum, the signature of diversifying selection is seen most strongly in Domain II of PvAMA-1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17244598
DOI: 10.1093/molbev/msm013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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