Article
Diversity and natural selection of Merozoite surface Protein-1 in three species of human malaria parasites: Contribution from South-East Asian isolates.
Molecular and biochemical parasitology - 1 Jul 2021
Goh Xiang Ting, Lim Yvonne A L, Lee Ping Chin, Nissapatorn Veeranoot, Chua Kek Heng
Abstract excerpt
The present study aimed to examine the genetic diversity of human malaria parasites (i.e., P. falciparum, P. vivax and P. knowlesi) in Malaysia and southern Thailand targeting the 19-kDa C-terminal region of Merozoite Surface Protein-1 (MSP-119). This region is essential for the recognition and invasion of erythrocytes and it is considered one of the leading candidates for asexual blood stage vaccines. However,...
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