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Article

Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma.

Diagnostic pathology - 22 Feb 2015

Zedan Walid, Mourad Mohamed I, El-Aziz Sherin M Abd, Salamaa Nagla M, Shalaby Asem A

Abstract excerpt

BACKGROUND: Cytogenetic analysis has detected an accumulation of genetic lesions in oral cancers. Numerical changes in chromosome 17 might be associated with an up-regulation of p53 gene, and could contribute to critical events in carcinogenesis. The aim of this study was to reveal possible correlations between the numerical aberrations of chromosome 17, deletion or amplification of the P53 gene and histological...

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Share to Carcinoma, Squamous Cell
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Head and Neck Neoplasms

Share to In Situ Hybridization, Fluorescence

Share to Mouth Neoplasms

Share to Neoplasm Grading

Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 25881131
DOI: 10.1186/s13000-015-0232-1
PMCID: PMC4340679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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