Article
Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations.
Oral oncology - 1 Jul 2000
Scully C, Field J K, Tanzawa H
Abstract excerpt
Carcinogenesis is the result of a series of genetic mutations resulting in unregulated growth of a clone of cells and the development of malignant lesion that is largely monoclonal though, with the evolution of further genetic changes, there develops a degree of heterogeneity in the tumour. DNA technology, especially allelic imbalance (loss of heterozygosity) studies have identified chromosomal changes in oral...
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