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Article

Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice.

Thrombosis and haemostasis - 1 Jul 2015

Pulakazhi Venu Vivek Krishna, Uboldi Patrizia, Dhyani Ashish, Patrini Alessandro, Baetta Roberta, Ferri Nicola, Corsini Alberto, Muro Andrés F, Catapano Alberico Luigi, Norata Giuseppe Danilo

Abstract excerpt

The primary transcript of fibronectin undergoes alternative splicing in the cassette-type EDA and EDB exons and in the IIICs segment to generate different protein isoforms. Human carotid atherosclerotic plaques with a more stable phenotype are enriched with EDA containing fibronectin (FN-EDA). The aim of this study was to investigate the role of EDA containing fibronectin during atherogenesis. Mice constitutively...

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Source

Identifiers

PMID: 25881051
DOI: 10.1160/TH14-09-0790

Genes

EDA
MMP2
MMP9
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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