Alternative splicing of fibronectin: a mouse model demonstrates the identity of in vitro and in vivo systems and the processing autonomy of regulated exons in adult mice.

Abstract excerpt

We have designed a novel approach using genetically engineered mice to make a systematic study of the EDA exon regulation of the fibronectin gene during development and aging. The genome of the mice was modified either by optimization of the EDA natural splice sites or by deleting the EDA region....

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