Article
Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics.
Cell communication and signaling : CCS - 31 Mar 2015
Bahlawane Christelle, Eulenfeld René, Wiesinger Monique Y, Wang Jiali, Muller Arnaud, Girod Andreas, Nazarov Petr V, Felsch Kathrin, Vallar Laurent, Sauter Thomas, Satagopam Venkata P, Haan Serge
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumours (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT or platelet-derived growth factor receptor-α (PDGFRα). Most mechanistic studies dealing with GIST mutations have focused on c-KIT and far less is known about the signalling characteristics of the mutated PDGFRα proteins. Here, we study the...
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