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Article

Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs.

Histopathology - 1 Jul 2009

Martinho Olga, Gouveia António, Viana-Pereira Marta, Silva Paula, Pimenta Amadeu, Reis Rui Manuel, Lopes José Manuel

Abstract excerpt

AIMS: Gastrointestinal stromal tumours (GISTs) are commonly driven by oncogenic mutations in KIT and PDGFRA. However, 10-40% of these patients are wild-type for these genes. The prognostic significance of wild-type GISTs is controversial, and they rarely respond to imatinib. The aim of this study...

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Share to Extracellular Signal-Regulated MAP Kinases
Share to Gastrointestinal Neoplasms
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase Kinases

Share to Proto-Oncogene Proteins B-raf

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Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 19614767
DOI: 10.1111/j.1365-2559.2009.03323.x

Genes

KIT
PDGFRA
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19614767-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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