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Article

Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis.

Arthritis research & therapy - 21 Mar 2015

Arismendi Maria, Giraud Matthieu, Ruzehaji Nadira, Dieudé Philippe, Koumakis Eugenie, Ruiz Barbara, Airo Paolo, Cusi Daniele, Matucci-Cerinic Marco, Salvi Erika, Cuomo Giovanna, Hachulla Eric, Diot Elisabeth, Caramaschi Paola, Riccieri Valeria, Avouac Jérôme, Kayser Cristiane, Allanore Yannick

Abstract excerpt

INTRODUCTION: Systemic sclerosis (SSc) and primary biliary cirrhosis (PBC) are rare polygenic autoimmune diseases (AIDs) characterized by fibroblast dysfunction. Furthermore, both diseases share some genetic bases with other AIDs, as evidenced by autoimmune gene pleiotropism. The present study wa...

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Identifiers

PMID: 25880423
DOI: 10.1186/s13075-015-0572-y
PMCID: PMC4422604

Genes

PLCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25880423-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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