Article
Update on primary sclerosing cholangitis genetics.
Current opinion in gastroenterology - 1 May 2014
Henriksen Eva K K, Melum Espen, Karlsen Tom H
Abstract excerpt
PURPOSE OF REVIEW: The pathogenesis of primary sclerosing cholangitis (PSC) involves heritable factors. This review summarizes the recent genetic studies and discusses the implications of identified risk loci. RECENT FINDINGS: A total of 16 PSC susceptibility loci have been identified in genome-wide association studies and related study designs. At least 33 additional loci are involved in what is increasingly...
Topics
- Animals
- Cholangitis, Sclerosing
- Disease Models, Animal
- Genetic Pleiotropy
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mice
- Translational Research, Biomedical