Article
The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.
Experimental neurology - 1 Dec 2020
Tiwari Durgesh, Schaefer Tori L, Schroeder-Carter Lindsay M, Krzeski Joseph C, Bunk Alexander T, Parkins Emma V, Snider Andrew, Danzer Reese, Williams Michael T, Vorhees Charles V, Danzer Steve C, Gross Christina
Abstract excerpt
The voltage-gated potassium channel Kv4.2 is a critical regulator of dendritic excitability in the hippocampus and is crucial for dendritic signal integration. Kv4.2 mRNA and protein expression as well as function are reduced in several genetic and pharmacologically induced rodent models of epilepsy and autism. It is not known, however, whether reduced Kv4.2 is just an epiphenomenon or a disease-contributing...
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