Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors.

Human molecular genetics - 15 Nov 2014

Koster Roelof, Mitra Nandita, D'Andrea Kurt, Vardhanabhuti Saran, Chung Charles C, Wang Zhaoming, Loren Erickson R, Vaughn David J, Litchfield Kevin, Rahman Nazneen, Greene Mark H, McGlynn Katherine A, Turnbull Clare, Chanock Stephen J, Nathanson Katherine L, Kanetsky Peter A

Abstract excerpt

Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding proteins important in male germ cell development. Deletions of one of these genes, DMRT1, lead to male-to-female sex reversal and are associated with development of gonadoblastoma. To further explore genetic association with TGCT, we undertook a pathway-based analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Neoplasms, Germ Cell and Embryonal

Share to Polymorphism, Single Nucleotide

Share to Sex Determination Processes

Share to Testicular Neoplasms

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24943593
DOI: 10.1093/hmg/ddu305
PMCID: PMC4204765

Genes

DMRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors.PMID 24943593Read ↗

Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor.Semantic proximity Read ↗

Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study.Semantic proximity Read ↗

Genetic changes associated with testicular cancer susceptibility.Semantic proximity Read ↗

Meta-analysis identifies four new loci associated with testicular germ cell tumor.Semantic proximity Read ↗

Identification of four new susceptibility loci for testicular germ cell tumour.Semantic proximity Read ↗

Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor.Semantic proximity Read ↗

Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility.Semantic proximity Read ↗

Identification of 22 susceptibility loci associated with testicular germ cell tumors.Semantic proximity Read ↗

A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.Semantic proximity Read ↗

Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application.Semantic proximity Read ↗

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.Semantic proximity Read ↗

Germline Exome Sequencing for Men with Testicular Germ Cell Tumor Reveals Coding Defects in Chromosomal Segregation and Protein-targeting Genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.