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Article

The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer

11 Jan 2016

Abstract excerpt

PURPOSE: The management of castration-resistant prostate cancer (CRPC) is a major challenge in the clinic. Androgen receptor signaling-directed strategies are not curative in CRPC therapy, and new strategies targeting alternative, key cancer properties are needed. Using reprogrammed glucose metabolism (aerobic glycolysis), cancer cells typically secrete excessive amounts of lactic acid into their...

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PMID: 26755530
DOI: 10.1158/1078-0432.ccr-15-1624

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