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Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

2026-01-07

Abstract excerpt

Cancer cells frequently rewire their metabolism to sustain growth and survival under stress. Despite the critical role of metabolic adaptation in tumorigenesis, how specific metabolic enzymes regulate lineage plasticity remains unclear. Here, through FDG-PET imaging and transcriptomic analyses, we reveal markedly elevated glucose uptake in neuroendocrine prostate cancer (NEPC) and identify glucokinase (GCK) as a M...

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Literature Corpus work
b9fca415-a600-5912-84d3-8cdaae1a4014
DOI
10.64898/2026.01.06.697917
Open publication

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Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1DOI 10.64898/2026.01.06.697917
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