Article
Constraint and divergence of global gene expression in the mammalian embryo.
eLife - 14 Apr 2015
Spies Noah, Smith Cheryl L, Rodriguez Jesse M, Baker Julie C, Batzoglou Serafim, Sidow Arend
Abstract excerpt
The effects of genetic variation on gene regulation in the developing mammalian embryo remain largely unexplored. To globally quantify these effects, we crossed two divergent mouse strains and asked how genotype of the mother or of the embryo drives gene expression phenotype genomewide. Embryonic expression of 331 genes depends on the genotype of the mother. Embryonic genotype controls allele-specific expression...
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