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Article

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

PloS one - 1 Jan 2011

Tang Fuchou, Barbacioru Catalin, Nordman Ellen, Bao Siqin, Lee Caroline, Wang Xiaohui, Tuch Brian B, Heard Edith, Lao Kaiqin, Surani M Azim

Abstract excerpt

Stochastic and deterministic allele specific gene expression (ASE) might influence single cell phenotype, but the extent and nature of the phenomenon at the onset of early mouse development is unknown. Here we performed single cell RNA-Seq analysis of single blastomeres of mouse embryos, which revealed significant changes in the transcriptome. Importantly, over half of the transcripts with detectable genetic...

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Identifiers

PMID: 21731673
DOI: 10.1371/journal.pone.0021208
PMCID: PMC3121735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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