Article
Systematic detection of polygenic cis-regulatory evolution.
PLoS genetics - 1 Mar 2011
Fraser Hunter B, Babak Tomas, Tsang John, Zhou Yiqi, Zhang Bin, Mehrabian Margarete, Schadt Eric E
Abstract excerpt
The idea that most morphological adaptations can be attributed to changes in the cis-regulation of gene expression levels has been gaining increasing acceptance, despite the fact that only a handful of such cases have so far been demonstrated. Moreover, because each of these cases involves only one gene, we lack any understanding of how natural selection may act on cis-regulation across entire pathways or...
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