Article
Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014
Mostafavi Sara, Ortiz-Lopez Adriana, Bogue Molly A, Hattori Kimie, Pop Cristina, Koller Daphne, Mathis Diane, Benoist Christophe
Abstract excerpt
To determine the breadth and underpinning of changes in immunocyte gene expression due to genetic variation in mice, we performed, as part of the Immunological Genome Project, gene expression profiling for CD4(+) T cells and neutrophils purified from 39 inbred strains of the Mouse Phenome Database. Considering both cell types, a large number of transcripts showed significant variation across the inbred strains,...
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