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Article

Genetic Variation of MT-ND Genes in Frontotemporal Lobar Degeneration: Biochemical Phenotype-Genotype Correlation.

Neuro-degenerative diseases - 1 Jan 2015

Gaspar Rita, Santana Isabel, Mendes Cândida, Fernandes Ana Sofia, Duro Diana, Simões Marta, Luís Daniela, Santos Maria João, Grazina Manuela

Abstract excerpt

BACKGROUND: Frontotemporal lobar degeneration (FTLD) is the second most common early-onset dementia. Over the last few decades, a growing number of evidence suggests mitochondrial involvement in neurodegeneration, namely modifications of mitochondrial DNA (mtDNA) contributing to energy impairment. OBJECTIVE: To sequence the 7 mitochondrially encoded complex I (MT-ND) genes in 70 FTLD patients and investigate...

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PMID: 25871488
DOI: 10.1159/000380766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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