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MOLECULAR ANALYSIS OF MITOCHONDRIAL COMPLEX I IN THE RESPONSIVENESS TO LEVODOPA IN PARKINSON’S DISEASE

2025-11-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Significant advances have been made in elucidating the pathophysiological mechanisms of Parkinson’s disease (PD). Levodopa remains the main therapeutic option — although it presents heterogeneous clinical benefits among patients. Mutations related to levodopa metabolic pathways have been investigated, but not for mtDNA. Since levodopa metabolism is highly dependent on ioni...

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Literature Corpus work: 0a23118e-ff79-5ac7-88cf-24d94450cdcd
DOI: 10.1101/2025.11.10.25339914

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