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Article

Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration.

Acta neuropathologica - 1 Jun 2022

Nie Yu, Murley Alexander, Golder Zoe, Rowe James B, Allinson Kieren, Chinnery Patrick F

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is a common cause of young onset dementia and is characterised by focal neuropathology. The reasons for the regional neuronal vulnerability are not known. Mitochondrial mechanisms have been implicated in the pathogenesis of FTLD, raising the possibility that frontotemporal regional mutations of mitochondrial DNA (mtDNA) are contributory causes. Here we applied dual...

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Identifiers

PMID: 35488929
DOI: 10.1007/s00401-022-02423-6
PMCID: PMC9107417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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