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Article

Does folic acid supplementation rescue defects in ECE-1-deficient mouse embryos?

Folia biologica - 1 Jan 2014

Haque A, Šaňková B, Kvasilová A, Krejčí E, Sedmera D

Abstract excerpt

Endothelin (ET) signalling is essential for normal embryonic development. Disruption of this pathway leads to defects in the development of subsets of cranial and cephalic neural crest derivatives. Endothelin-converting enzyme 1 (ECE-1) is a ratelimiting step in the biosynthesis of ET-1. Recently, there has been considerable interest in the protective role of folic acid (FA) against congenital anomalies via...

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Share to Aspartic Acid Endopeptidases
Share to Dietary Supplements
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunohistochemistry

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Share to Mice, Knockout

Source

Identifiers

PMID: 25863042
DOI: 10.14712/fb2014060050244

Genes

ECE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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