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Article

Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies

29 Jul 2009

Abstract excerpt

Elevated plasma homocysteine (HCy), which results from folate (folic acid, FA) deficiency, and the mood-stabilizing drug lithium (Li) are both linked to the induction of human congenital heart and neural tube defects. We demonstrated previously that acute administration of Li to pregnant mice on embryonic day (E)6.75 induced cardiac valve defects by potentiating Wnt-beta-catenin signaling. We hypothesized that...

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PMID: 19638421
DOI: 10.1242/dmm.001438

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