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Article

SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects.

Journal of molecular biology - 4 Apr 2008

Johansson Denny G A, Macao Bertil, Sandberg Anders, Härd Torleif

Abstract excerpt

A subclass of SEA (sea urchin sperm protein, enterokinase, and agrin) domain proteins undergoes autoproteolysis between glycine and serine in a conserved G(-1)S+1VVV motif to generate stable heterodimers. Autoproteolysis has been suggested to involve only the intramolecular catalytic action of the conserved serine hydroxyl in combination with conformational strain of the glycine-serine peptide bond. We conducted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 18314133
DOI: 10.1016/j.jmb.2008.01.050

Genes

SEA
MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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