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Article

Conformational dynamics and energetic perturbations in human β-spectrin-II mediated by calpain cleavage-related mutations: Insights from enhanced sampling simulations.

Computational biology and chemistry - 1 Feb 2026

Kizhakethil Reshma V, Varma Ashok K, Bhogale Om V, Joshi Manasvi A, Barage Sagar H, Kumar Aruni Wilson Santhosh, Kamble Shashank S

Abstract excerpt

The present study examined the impact of missense mutations in calpain substrates on their interaction with calpains and subsequent cellular functions. Calpains are a family of calcium-dependent cysteine proteases that modify the activity or location of their substrate proteins through cleavage at specific sites in a strictly controlled manner. Recent reports suggested the presence of missense mutations within...

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PMID: 41192394
DOI: 10.1016/j.compbiolchem.2025.108759

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SPTB

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