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Article

Polymorphisms in folate pathway genes are not associated with somatic nondisjunction in turner syndrome.

American journal of medical genetics. Part A - 1 Jul 2015

Bispo Adriana Valéria Sales, dos Santos Luana Oliveira, de Barros Juliana Vieira, Duarte Andrea Rezende, Araújo Jacqueline, Muniz Maria Tereza Cartaxo, Santos Neide

Abstract excerpt

Folate metabolism dysfunction can lead to DNA hypomethylation and abnormal chromosomal segregation. Previous investigations of this association have produced controversial results. Here we performed a case-control study in patients with Turner syndrome (TS) to determine the effects of genetic polymorphisms of folate pathway genes as potential risk factors for somatic chromosomal nondisjunction. TS is a useful...

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Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cytogenetic Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Nondisjunction, Genetic

Share to Replication Protein C

Share to Thymidylate Synthase

Share to Turner Syndrome

Source

Identifiers

PMID: 25858821
DOI: 10.1002/ajmg.a.37055

Genes

MTHFR
MTR
RFC1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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