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Article

Maternal folate polymorphisms and the etiology of human nondisjunction.

American journal of human genetics - 1 Aug 2001

Hassold T J, Burrage L C, Chan E R, Judis L M, Schwartz S, James S J, Jacobs P A, Thomas N S

Abstract excerpt

Attempts to identify genetic contributors to human meiotic nondisjunction have met with little, if any, success. Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest. In the present report, we asked whether variation at MTHFR...

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Source

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Identifiers

PMID: 11443546
DOI: 10.1086/321971
PMCID: PMC1235315

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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