Article
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2015
Ogese M O, Saide K, Faulkner L, Whitaker P, Peckham D, Alfirevic A, Baker D M, Sette A, Pirmohamed M, Park B K, Naisbitt D J
Abstract excerpt
BACKGROUND: For certain HLA allele-associated drug hypersensitivity reactions, the parent drug has been shown to associate directly with the risk allele. In other forms of hypersensitivity, HLA risk alleles have not been identified and T cells are activated in an allele unrestricted manner. Chemically reactive drug metabolites bind to multiple proteins; thus, it is assumed that the derived peptide antigens...
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