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Article

The structural basis of <scp>HLA</scp>‐associated drug hypersensitivity syndromes

10 Oct 2012

Abstract excerpt

Recent data suggest alternative mechanisms that promote human leukocyte antigen (HLA)-associated drug syndromes. Hypersensitive responses have been attributed to drug interactions with HLA molecules, peptides presented by HLA molecules and T-cell antigen receptors. Definition of an increasing number of HLA-associated drug syndromes suggests that polymorphism in the antigen-binding cleft residues influence...

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PMID: 23046128
DOI: 10.1111/j.1600-065x.2012.01163.x

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