Article

Generation and characterization of dapsone- and nitroso-dapsone-specific T-cells : an insight into the molecular pathomechanism of dapsone hypersensitivity syndrome

2018-01-01

Abstract excerpt

Dapsone (DDS) is an antibiotic associated with hypersensitivity reactions in 0.5 to 3.6 % of patients. Although clinical diagnosis is indicative of a drug hypersensitivity reaction, studies have not been performed to define whether dapsone or a metabolite activates specific T-cells. Thus, the aims of this study were to (i) explore the immunogenicity DDS and nitroso DDS (DDS-NO) using PBMC from healthy donors and s...

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Literature Corpus work: 04704b7d-bced-5cbf-bb85-5c4474176ac1
DOI: 10.17638/03023184

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