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Article

Pharmacogenetic Role of Dopamine Transporter (SLC6A3) Variation on Response to Disulfiram Treatment for Cocaine Addiction

14 May 2019

Abstract excerpt

BACKGROUND AND OBJECTIVES: Disulfiram has been beneficial in treating cocaine addiction in several studies. Patients with two SLC6A3 (DAT1) rs28363170 10-repeat alleles who have with genetically high dopamine transporter (DAT) levels may benefit from increased dopamine levels resulting from disulfiram treatment. METHODS: After stabilization for 2 weeks on methadone, 70 cocaine and opioid codependent patients were...

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PMID: 31087723
DOI: 10.1111/ajad.12891

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