Article
Genetic risk factors affecting mitochondrial function are associated with kidney disease in people with Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association - 1 Aug 2015
Swan E J, Salem R M, Sandholm N, Tarnow L, Rossing P, Lajer M, Groop P H, Maxwell A P, McKnight A J
Abstract excerpt
AIM: To evaluate the association with diabetic kidney disease of single nucleotide polymorphisms (SNPs) that may contribute to mitochondrial dysfunction. METHODS: The mitochondrial genome and 1039 nuclear genes that are integral to mitochondrial function were investigated using a case (n = 823 individuals with diabetic kidney disease) vs. control (n = 903 individuals with diabetes and no renal disease) approach....
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