Article

Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome

2024-12-11

Abstract excerpt

<h4>Background</h4> Flecainide and other class-Ic antiarrhythmic drugs (AADs) are widely used in Andersen-Tawil syndrome type 1 (ATS1) patients. However, class-Ic drugs might be proarrhythmic in some cases. We investigated the molecular mechanisms of class-I AADs proarrhythmia and whether they might increase the risk of death in ATS1 patients with structurally normal hearts. <h4>Methods and Results</h4> Of 53 ATS1...

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Literature Corpus work: ff91d63d-6136-5d2f-80a0-93c027716665
DOI: 10.1101/2024.12.10.24318629

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