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Article

Domain movements during CCA-addition: a new function for motif C in the catalytic core of the human tRNA nucleotidyltransferases.

RNA biology - 1 Jan 2015

Ernst Felix G M, Rickert Christian, Bluschke Alexander, Betat Heike, Steinhoff Heinz-Jürgen, Mörl Mario

Abstract excerpt

CCA-adding enzymes are highly specific RNA polymerases that synthesize and maintain the sequence CCA at the tRNA 3'-end. This nucleotide triplet is a prerequisite for tRNAs to be aminoacylated and to participate in protein biosynthesis. During CCA-addition, a set of highly conserved motifs in the catalytic core of these enzymes is responsible for accurate sequential nucleotide incorporation. In the nucleotide...

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Identifiers

PMID: 25849199
DOI: 10.1080/15476286.2015.1018502
PMCID: PMC4615804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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