Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Domain movements during CCA-addition: a new function for motif C in the catalytic core of the human tRNA nucleotidyltransferases.

RNA biology - 1 Jan 2015

Ernst Felix G M, Rickert Christian, Bluschke Alexander, Betat Heike, Steinhoff Heinz-Jürgen, Mörl Mario

Abstract excerpt

CCA-adding enzymes are highly specific RNA polymerases that synthesize and maintain the sequence CCA at the tRNA 3'-end. This nucleotide triplet is a prerequisite for tRNAs to be aminoacylated and to participate in protein biosynthesis. During CCA-addition, a set of highly conserved motifs in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Molecular Docking Simulation
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Tertiary

Share to RNA Nucleotidyltransferases

Share to RNA, Transfer

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 25849199
DOI: 10.1080/15476286.2015.1018502
PMCID: PMC4615804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25849199-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Domain movements during CCA-addition: a new function for motif C in the catalytic core of the human tRNA nucleotidyltransferases.PMID 25849199Read ↗

Mechanism of human tRNA 3’CCA maturationSemantic proximity Read ↗

Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase.Semantic proximity Read ↗

The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.Semantic proximity Read ↗

The ability of an arginine to tryptophan substitution in Saccharomyces cerevisiae tRNA nucleotidyltransferase to alleviate a temperature-sensitive phenotype suggests a role for motif C in active site organization.Semantic proximity Read ↗

Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.Semantic proximity Read ↗

Thumb-domain dynamics modulate the functional repertoire of DNA-Polymerase IV (DinB).Semantic proximity Read ↗

Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases.Semantic proximity Read ↗

Insights into catalysis by a knotted TrmD tRNA methyltransferase.Semantic proximity Read ↗

Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis.Semantic proximity Read ↗

Poly(C) synthesis by class I and class II CCA-adding enzymes.Semantic proximity Read ↗

Dimerization and Threonine-Dependent Stabilization Govern Human YRDC CatalysisSemantic proximity Read ↗

The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.