Article
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.
Nucleic acids research - 1 Oct 2010
Guelorget Amandine, Roovers Martine, Guérineau Vincent, Barbey Carole, Li Xuan, Golinelli-Pimpaneau Béatrice
Abstract excerpt
The S-adenosyl-L-methionine dependent methylation of adenine 58 in the T-loop of tRNAs is essential for cell growth in yeast or for adaptation to high temperatures in thermophilic organisms. In contrast to bacterial and eukaryotic tRNA m(1)A58 methyltransferases that are site-specific, the homologous archaeal enzyme from Pyrococcus abyssi catalyzes the formation of m(1)A also at the adjacent position 57, m(1)A57...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.