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Article

The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.

Biochemistry - 27 Nov 2001

Kaminska M, Shalak V, Mirande M

Abstract excerpt

An ancillary RNA-binding domain is appended to the C-terminus of human methionyl-tRNA synthetase. It comprises a helix-turn-helix (HTH) motif related to the repeated units of the linker region of bifunctional glutamyl-prolyl-tRNA synthetase, and a specific C-terminal KGKKKK lysine-rich cluster (LRC). Here we show by gel retardation and tRNA aminoacylation experiments that these two regions are important for tRNA...

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PMID: 11714285
DOI: 10.1021/bi015670b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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